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OUR RESEARCH

The primary focus of our work is on the study of sex differences in lung disease outcomes, and on the role of sex hormones in the control of air pollution-induced lung inflammation. 

 

Our commitment to studying sex-specific mechanisms of lung inflammation is based on accumulating evidence reporting gender differences in lung disease susceptibility, and disparities in the efficacy of available treatments.

Check out our current projects and recent publications.

Over the years, we have been supported by:

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CURRENT PROJECTS

* Sex differences in lung inflammatory responses to environmental exposures 

* The effect of the female reproductive cycle in lung inflammatory responses and asthma exacerbations

* Estradiol and progesterone's effects on pollution-induced lung inflammation

* Mechanisms of estrogen and progesterone receptor regulation of lung inflammation

* Sex differences in airway remodeling during asthma and ozone-induced asthma exacerbations

ACTIVE FUNDING

Federal grants:

5R01HL159764-03    

Silveyra (PI)                                                               

07/10/21-06/30/25

Gonadal hormones as mediators of sex and gender influences in asthma 

 

3R01HL159764-02S1

Silveyra (PI), Diversity supplement to Dr. Sarah Commodore                                 

09/09/22-06/30/25

Gonadal hormones as mediators of sex and gender influences in asthma

 

3 R01 HL159764-03W1

Silveyra (PI), DEIA administrative supplement (REAL-DEAL program)                                                                   

08/01/23-07/31/24

Promoting DEIA in Lung Disease Research Through a Mentored Training Experience at IUB-SPH         

Indiana University Pilot Funds:

- Sex-specific lung functional changes in mice exposed to electronic cigarettes in utero

- Chemical fingerprinting of federally regulated and non-regulated e-cig liquids and aerosols by Q-TOF gas chromatography-mass spectrometry

- Phthalate exposure and asthma phenotypes: sex-specific mechanisms

Collaboration grants:

- Predictors and diagnostic biomarkers of pulmonary hypertension associated with severe bronchopulmonary dysplasia (PSU)

- Scientific innovation for personalized severe asthma management (IUPUI)

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